Today, I tried to make a Release Build of a rather large solution and I got this exception:
Could not load file or assembly ‘file:///C:\some.dll’ or one of its dependencies. Operation is not supported. (Exception from HRESULT: 0×80131515) C:\somepath\SGEN
The solution is simpler than it looks like:
The DLL was downloaded from the web and somehow, Windows “blocked”. To unblock it, just right-click the DLL in your explorer and click the “Unblock” button (make sure, you have write access to the file).
That’s all what is needed to fix this problem (at least in my case).